Thou... Infectious Boil-brained Coxcomb

Parts of what makes up this insult can be found in "Antony and Cleopatra" spoken by "CLEOPATRA":
Madam, he's married to Octavia.
The most infectious pestilence upon thee!
Strikes him down
This insult has been seen 2 times on this site. The first time was on Monday, April 8th, 2019
Thou... Art Here to be Insulted and Humored

A total of 9951 insults have been uniquely generated 10379 times, with a total of 125000 (or 50 to the third power) insults available in the system!